Step 1: Login to your Duo Security account here - https://admin.duosecurity.com/login
If you are new to Duo Security, you can sign up for your account here - https://signup.duosecurity.com/ and then log in.
Step 2: Once you are logged in, click on Applications from the menu on the left.
Step 3: In the Applications page, click on the blue [ + Add an Application ] button on the right.
Step 5: In the next page, under Details you will see 3 fields - Integration key, Secret key and API hostname. Copy and paste each of the values in the text fields to the corresponding fields in your admin panel under Settings → Security → Two-Factor Authentication → Duo Security. Enter the corresponding values and then hit Save Changes.
For paid plans, make sure the [ ] Let users manage their devices option is checked. This will allow users to manage their devices.